| 26.08.1922 | Crystal Palace | 2 | - | 1 | W | 30.000 | LgDiv1 | H | Old Trafford | Joe Spence, John Wood | |||||
| 02.09.1922 | Crystal Palace | 3 | - | 2 | W | 8.500 | LgDiv2 | U | Selhurst Park | Joe Spence x2, Harry Williams | |||||
| 12.04.1924 | Crystal Palace | 5 | - | 1 | W | 8.000 | LgDiv2 | H | Old Trafford | Thomas Smith, Joe Spence x4 | |||||
| 19.04.1924 | Crystal Palace | 1 | - | 1 | D | 7.000 | LgDiv2 | U | Selhurst Park | Joe Spence | |||||
| 11.10.1924 | Crystal Palace | 1 | - | 0 | W | 27.750 | LgDiv2 | H | Old Trafford | Arthur Lochhead | |||||
| 14.02.1925 | Crystal Palace | 1 | - | 2 | L | 11.250 | LgDiv2 | U | Selhurst Park | Arthur Lochhead | |||||
| 09.08.1969 | Crystal Palace | 2 | - | 2 | D | 48.610 | LgDiv1 | U | Selhurst Park | Bobby Charlton, Willie Morgan | |||||
| 14.02.1970 | Crystal Palace | 1 | - | 1 | D | 54.711 | LgDiv1 | H | Old Trafford | Brian Kidd | |||||
| 10.10.1970 | Crystal Palace | 0 | - | 1 | L | 42.979 | LgDiv1 | H | Old Trafford | ||||||
| 18.11.1970 | Crystal Palace | 4 | - | 2 | W | 48.961 | LCup | R5 | H | Old Trafford | John Fitzpatrick, Brian Kidd x2, Bobby Charlton | ||||
| 17.04.1971 | Crystal Palace | 5 | - | 3 | W | 39.145 | LgDiv1 | U | Selhurst Park | Denis Law 43', 48', 66', George Best 58', 65' | |||||
| 11.09.1971 | Crystal Palace | 3 | - | 1 | W | 44.020 | LgDiv1 | U | Selhurst Park | Brian Kidd, Denis Law x2 | |||||
| 25.03.1972 | Crystal Palace | 4 | - | 0 | W | 41.550 | LgDiv1 | H | Old Trafford | Alan Gowling, Bobby Charlton, Storey-Moore, Denis Law | |||||
| 16.12.1972 | Crystal Palace | 0 | - | 5 | L | 39.484 | LgDiv1 | U | Selhurst Park | ||||||
| 11.04.1973 | Crystal Palace | 2 | - | 0 | W | 46.891 | LgDiv1 | H | Old Trafford | Brian Kidd 27', Willie Morgan 34' | |||||
| 17.11.1979 | Crystal Palace | 1 | - | 1 | D | 52.800 | LgDiv1 | H | Old Trafford | Joe Jordan 9 ' | |||||
| 29.03.1980 | Crystal Palace | 2 | - | 0 | W | 33.056 | LgDiv1 | U | Selhurst Park | Joe Jordan, Mickey Thomas | |||||
| 01.11.1980 | Crystal Palace | 0 | - | 1 | L | 31.449 | LgDiv1 | U | Selhurst Park | ||||||
| 04.04.1981 | Crystal Palace | 1 | - | 0 | W | 37.954 | LgDiv1 | H | Old Trafford | Mike Duxbury | |||||
| 24.09.1985 | Crystal Palace | 1 | - | 0 | W | 21.507 | LCup | R2-1 | U | Selhurst Park | Peter Barnes 59' | ||||
| 09.10.1985 | Crystal Palace | 1 | - | 0 | W | 26.118 | LCup | R2-2 | H | Old Trafford | Norman Whiteside 1' | ||||
| 28.10.1987 | Crystal Palace | 2 | - | 1 | W | 27.283 | LCup | R3 | H | Old Trafford | Brian McClair 7' (pen), 28' | ||||
| 22.08.1989 | Crystal Palace | 1 | - | 1 | D | 22.423 | LgDiv1 | U | Selhurst Park | Bryan Robson 19' | |||||
| 09.12.1989 | Crystal Palace | 1 | - | 2 | L | 33.514 | LgDiv1 | H | Old Trafford | Russel Beardsmore 9' | |||||
| 12.05.1990 | Crystal Palace | 3 | - | 3 | D | 80.000 | FACup | F | aet | N | Wembley | Bryan Robson 35', Mark Hughes 62, 113' | |||
| 17.05.1990 | Crystal Palace | 1 | - | 0 | W | 80.000 | FACup | Frp | N | Wembley | Lee Martin 59' | ||||
| 03.11.1990 | Crystal Palace | 2 | - | 0 | W | 45.724 | LgDiv1 | H | Old Trafford | Neil Webb 11', Danny Wallace 19' | |||||
| 11.05.1991 | Crystal Palace | 0 | - | 3 | L | 25.301 | LgDiv1 | U | Selhurst Park | ||||||
| 30.11.1991 | Crystal Palace | 3 | - | 1 | W | 29.017 | LgDiv1 | U | Selhurst Park | Neil Webb 26', Brian McClair 57', Andrei Kanchelskis 58' | |||||
| 22.02.1992 | Crystal Palace | 2 | - | 0 | W | 46.347 | LgDiv1 | H | Old Trafford | Mark Hughes 11', 51' | |||||
| 02.09.1992 | Crystal Palace | 1 | - | 0 | W | 29.736 | LgPL | H | Old Trafford | Mark Hughes 88' | |||||
| 21.04.1993 | Crystal Palace | 2 | - | 0 | W | 30.115 | LgPL | U | Selhurst Park | Mark Hughes 64', Paul Ince 89' | |||||
| 19.11.1994 | Crystal Palace | 3 | - | 0 | W | 43.788 | LgPL | H | Old Trafford | Denis Irwin 8', Eric Cantona 34', Andrei Kanchelskis 51' | |||||
| 25.01.1995 | Crystal Palace | 1 | - | 1 | D | 18.224 | LgPL | U | Selhurst Park | David May 57' | |||||
| 09.04.1995 | Crystal Palace | 2 | - | 2 | D | 38.256 | FACup | SF | aet | N | Villa Park | Denis Irwin 70', Gary Pallister 97' | |||
| 12.04.1995 | Crystal Palace | 2 | - | 0 | W | 17.987 | FACup | SFrp | N | Villa Park | Steve Bruce 30', Gary Pallister 41' | ||||
| 04.10.1997 | Crystal Palace | 2 | - | 0 | W | 55.143 | LgPL | H | Old Trafford | Teddy Sheringham 18', Herman Hreidarsson 30' (o.g.) | |||||
| 27.04.1998 | Crystal Palace | 3 | - | 0 | W | 26.180 | LgPL | U | Selhurst Park | Paul Scholes 6', Nicky Butt 22', Andrew Cole 84' | |||||
| 10.11.2004 | Crystal Palace | 2 | - | 0 | W | 48.891 | LCup | R4 | H | Old Trafford | Louis Saha 22', Kieran Richardson 39' | ||||
| 18.12.2004 | Crystal Palace | 5 | - | 2 | W | 67.814 | LgPL | H | Old Trafford | Paul Scholes 22', 49', Alan Smith 35', Emerson Boyce 48' (o.g.), John O'Shea 90' | |||||
| 05.03.2005 | Crystal Palace | 0 | - | 0 | D | 26.021 | LgPL | U | Selhurst Park | ||||||
| 30.11.2011 | Crystal Palace | 1 | - | 2 | L | 52.624 | LCup | R5 | aet | H | Old Trafford | Federico Macheda 69' (pen) |
| 14.09.2013 | Crystal Palace | 2 | - | 0 | W | 75.012 | LgPL | H | Old Trafford | Robin van Persie 45'+1 (pen), Wayne Rooney 81' | |||||
| 22.02.2014 | Crystal Palace | 2 | - | 0 | W | 24.571 | LgPL | U | Selhurst Park | Robin van Persie 62' (pen), Wayne Rooney 68' | |||||
| 08.11.2014 | Crystal Palace | 1 | - | 0 | W | 75.325 | LgPL | H | Old Trafford | Juan Mata 67' | |||||
| 09.05.2015 | Crystal Palace | 2 | - | 1 | W | 25.009 | LgPL | U | Selhurst Park | Juan Mata 19' (pen), Marouane Fellaini 78' | |||||
| 31.10.2015 | Crystal Palace | 0 | - | 0 | D | 24.854 | LgPL | U | Selhurst Park | ||||||
| 20.04.2016 | Crystal Palace | 2 | - | 0 | W | 75.277 | LgPL | H | Old Trafford | Damien Delaney 4' (o.g.), Matteo Darmian 55' | |||||
| 21.05.2016 | Crystal Palace | 2 | - | 1 | W | 88.619 | FACup | F | N | Wembley | Juan Mata 81', Jesse Lingard 110' | ||||
| 14.12.2016 | Crystal Palace | 2 | - | 1 | W | 25.547 | LgPL | U | Selhurst Park | Paul Pogba 45'+2, Zlatan Ibrahimovic 88' | |||||
| 21.05.2017 | Crystal Palace | 2 | - | 0 | W | 75.254 | LgPL | H | Old Trafford | Josh Harrop 15', Paul Pogba 19' | |||||
| 30.09.2017 | Crystal Palace | 4 | - | 0 | W | 75.118 | LgPL | H | Old Trafford | Juan Mata 3', Marouane Fellaini 35', 49', Romelu Lukaku 86' | |||||
| 05.03.2018 | Crystal Palace | 3 | - | 2 | W | 25.840 | LgPL | U | Selhurst Park | Chris Smalling 55', Romelu Lukaku 76', Nemanja Matic 90'+1 | |||||
| 24.11.2018 | Crystal Palace | 0 | - | 0 | D | 74.516 | LgPL | H | Old Trafford | ||||||
| 27.02.2019 | Crystal Palace | 3 | - | 1 | W | 25.754 | LgPL | U | Selhurst Park | Romelu Lukaku 33', 52', Ashley Young 83' |